Formulation and Evaluation of Oral Elementary Osmotic Pump Tablets of Sumatriptan Succinate

Development and Evaluation of Swellable Elementary Osmotic Pump Tablets of Metoprolol Succinate and Ramipril

Swellable elementary osmotic pump (SEOP)utilizes the osmotic pressure and polymer-swelling force to deliver drugs to the GI tract in a reliable and reproducible manner.Metoprolol and ramipril are one of the combinationsindicated in the management of hypertension in patients with heart failure and post myocardial infarction. This combination was selected to develop SEOP to release the drugs cont...

Formulation and evaluation of bilayered tablets of sumatriptan succinate by using hydrophilic polymers

Bi-layered [1] tablet refers to tablet which contain subunits. In bi-layer [2] tablets, one layer tablet provides immediate release and the other layer acts as sustained release. Sumatriptan is a new class of anti-migraine [3] drugs that selectively activate 5-HT1B/1D receptors and are called triptans. Our objective is to formulate and evaluate the bi-layer tablets of sumatriptan succinate of d...

Formulation And In Vitro Evaluation Of Sumatriptan Succinate Oral Thin Films

Formulation & Evaluation of Oral Disintegrating Tablets of Lamotrigine Solid Dispersions

Lamotrigine is used in the treatment of CNS disorders, particularly epilepsy; pain; oedema; multiple sclerosis and psychiatric indications including bipolar disorder. Lamotrigine belongs to biopharmaceutical classification systems, BCS class II (Low solubility & High permeability). In addition, it requires immediate therapeutic action hence the main objective of this study is to improve the sol...

In vivo bioavailability studies of sumatriptan succinate buccal tablets

UNLABELLED BACK GROUND AND THE PURPOSE OF STUDY: Sumatriptan succinate is a Serotonin 5- HT1 receptor agonist, used in treatment of migraine. It is absorbed rapidly but incompletely when given orally and undergoes first-pass metabolism, resulting in a low absolute bioavailability of about 15%. The aim of this work was to design mucoadhesive bilayered buccal tablets of sumatriptan succinate to ...